Objective:

To investigate the clinical value of the quantitative model of contrast-enhanced ultrasound (CEUS) time- intensity curve (TIC) in the evaluation of the therapeutic efficacy during concurrent chemoradiotherapy (CCRT) for advanced cervical cancer.

Methods:

Sixteen patients with advanced cervical cancer who received CCRT in the Department of Radiation Oncology at Jiangsu Cancer Hospital from August 2018 to August 2020 were selected. All patients underwent transvaginal CEUS before treatment

at 2 weeks of treatment

and after completion of external irradiation. CEUS combin

ed with TIC quantitative analysis was conducted.

Results:

Both the overall patient group and TP group showed significantly shortened time to peak enhancement at 2 weeks into CCRT treatment and after external irradiation compared to before treatment. The TP group exhibited a significant increase in the area under the curve at 2 weeks into treatment compared to before treatment.

Conclusion:

The combined use of CEUS and TIC analysis can reflect changes in tumor perfusion after CCRT treatment for advanced cervical cancer

providing a certain value in early therapeutic efficacy assessment.