Objective:

To investigate the gray scale ultrasound

color Doppler ultrasound and ultrasonic elastography findings of solid papillary carcinoma of the breast (SPC)

and to explore the correlation between the ultrasound findings of SPC and its pathology.

Methods:

The clinical data of 71 patients with SPC confirmed by surgery and pathology were analyzed

including gray scale and color Doppler ultrasound findings of 75 SPC lesions and ultrasonic elastogra

phy findings of 35 SPC lesions. To compare the ultrasonographic features and pathological correlation of different pathological subtypes of SPC.

Results:

Most of the sonographic manifestations of SPC were solitary hypoechoic solid masses with parallel origin

irregular shape

ill-defined margin

enhanced or unchanged posterior echo

and could be accompanied by duct dilation and calcification. Adler blood flow grade was Ⅱ-Ⅲ

and the resistance index (RI) range was 0.62-0.84. There was almost no axillary lymph node metastasis. The pathological molecular subtype of 75 SPC lesions was Luminal A type. Ki-67 proliferation index was ＜20% in 42 in situ SPC lesions

and the expression range was 20%-60% in 15 invasive SPC lesions

with a statistically significant difference between the subtypes (

P

=0.000).

Conclusion:

The ultrasound manifestations of SPC has certain characteristics. Combining gray scale

color Doppler

and ultrasonic elastography can improve the diagnostic accuracy. Ultrasound cannot distinguish between in situ SPC and invasive SPC. The Ki-67 proliferation index is related to whether SPC is infiltrating.