Breast cancer is the most prevalent malignancy in women worldwide and the leading cause of death from malignancy in women. Early diagnosis and treatment can effectively improve the survival rate of breast cancer patients. Contrast-enhanced ultrasound is a non-invasive

real-time screening tool for qualitative and quantitative analysis of lesions by injecting microbubbles with enhanced acoustic impedance into the body

and its combined application with new technologies such as radiomics and molecular imaging has potential clinical applications in early diagnosis and efficacy assessment of breast cancer. This article reviewed the research progress of contrast-enhanced ultrasound and related new technologies in the diagnosis and treatment of breast cancer.