Objective:

To investigate ultrasound sonographic characteristics of different molecular subtypes of breast cancer in young women under the age of 40 years.

Methods:

A retrospective analysis of 60 young patients diagnosed in The Affiliated Hospital of Nanjing University of Chinese Medicine from January 2019 to May 2023 was conducted

who had received breast ultrasound examination and breast ca

ncer resection

then they were pathologically confirmed as breast cancer after surgery. The cases were divided into type Luminal A

type Luminal B

triple-negative type and human epidermal growth factor receptor 2 (HER2) overexpression type according to immunohistochemistry. The ultrasound characteristics of different subtypes in the maximum diameter

the orientation

the aspect ratio

the shape

the boundary

marginal spiculate

internal echo

calcification

posterior echo

the blood flow grade

and the elastic score of the mass were analyzed.

Results:

In 60 breast cancer cases

Luminal A type was relatively common (40.0%)

while the HER2 overexpression type was the rarest (15.0%). Among different molecular subtypes

the differences in the marginal burr

calcification and posterior echo of the mass were statistically significant (

P

＜0.05)

among which the Luminal A type and Luminal B type mainly showed marginal spiculate (79.2%

55.3%)

the triple-negative type mainly showed enhancement or with no change (91.7%)

and HER2 overexpression type mainly showed calcification (88.9%). However

there was no statistical significance in the maximum diameter

the orientation

the aspect ratio

the shape

the boundary

internal echo

the blood flow grade

and the elasticity score of the mass (

P

＞0.05).

Conclusion:

The ultrasound sonographic characteristics of young female patients with breast cancer are associated with their molecular subtypes

which can provide a valuable reference for predicting the molecular subtypes of breast cancers before a surgery.