Objective:

To investigate the value of characteristics of conventional ultrasound combined with contrast-enhanced ultrasound (CEUS) in predicting the recurrence or metastasis of postoperative breast cancer patients.

Methods:

A total of 139

patients with breast cancer in Nanjing Medical University First Hospital confirmed by pathology and subsequently underwent surgical resection from January 2016 to December 2017 were selected in this study

and the recurrence or metastasis of these patients within five years were analyzed

including 126 patients without recurrence or metastasis and 13 patients with recurrence or metastasis (3 patients with recurrence and 10 patients with metastasis). The correlation between the characteristics of conventional ultrasound combined with CEUS and the recurrence or metastasis of postoperative breast cancer in the two groups was determined by univariate analyses. Logistic regression was used to screen out the risk factors and establish a model to analyze its diagnostic efficacy.

Results:

Univariate analysis showed that the uniformity of enhancement (uneven)

lesion edges after enhancement (blurry)

tumor orientation (vertical) and lymph node blood flow (non-lymphoid portal type) were correlated with the recurrence or metastasis of postoperative breast cancer. Multivariable logistic regression showed that the uniformity of enhancement (OR=5.686

P

=0.047)

tumor orientation (OR=5.190

P

=0.015) and lymph node blood flow (OR=6.725

P

=0.006) were independent risk factors for recurrence or metastasis in postoperative breast cancer patients. Logistic regression analysis was used to screen out the risk factors and establish conventional ultrasound combined with CEUS model. The area under the receiver operating characteristic (ROC) curve for uniformity of enhancement

tumor orientation

lymph node blood flow and conventional ultrasound combined with CEUS modelwere 0.677

0.677

0.685 and 0.841 respectively.

Conclusion:

The conventional ultrasound combined with CEUS model established in this study has certain application value in predicting the recurrence or metastasis of postoperative breast cancer. It provides the reference basis for breast surgeons to improve the tre

atment plan for patients with recurrence risk before treatment.