Objective:

To explore the clinical significance of ultrasonic myocardial work index in evaluating cancer therapy-related cardiac dysfunction (CTRCD) after breast cancer chemotherapy.

Methods:

A total of 45 women with human epidermal growth factor receptor 2 (HER2)

+

breast cancer who received anthracycline sequential therapy participated in Nanjing Lishui District People’s Hospital from January 2021 to June 2022 were selected

including 33 patients with non-CTRCD and 12 patients with CTRCD. All patients were examined by two-dimensional transthoracic echocardiography and two-dimensional speckle tracking imaging (STI) before starting anthracycline therapy (T

0

)

after 2 cycles of anthracycline chemotherapy (T

1

)

after 4 cycles (T

2

) and at the end of the whole chemotherapy cycle (T

3

).

Results:

In patients without CTRCD

the trajectories of GLS

GWI and GCW were significantly different (

P

＜0.001

0.017 and 0.006

respectively). During the whole chemotherapy period

GLS

GWI and GCW of patients with CTRCD decreased in a time-dependent manner (

P

＜0.05)

and reached the lowest level at T

3

. Multivariateanalysis showed that GLS ［OR (95% CI)=1.94 (1.02-3.69)

P

=0.044］ and GWI ［OR (95% CI)=1.78 (1.05-3.03)

P

=0.032］ was independently related to CTRCD. The area under curve (AUC) of GLS and GWI in T

1

as independent predictors of CTRCD were 0.749 (95% CI 0.550-0.948) and 0.837 (95% CI 0.675-0.998)

respectively. When GLS and GWI were combined in T

1

phase

the AUC of diagnosing CTRCD increased to 0.942 (95% CI 0.878-1.000)

and the sensitivity and specificity were 74.7% and 92.1% respectively.

Conclusion:

Left ventricular GLS and GWI can be used as independent predictors of anthrac

ycline-induced CTRCD.