Objective:

To investigate the value of diffusion-w

eighted imaging (DWI) with different parameters in preoperative evaluation of lymphovascular space invasion (LVSI) of endometrial carcinoma (EC).

Methods:

The clinical and pathological data of 146 cases of EC were retrospectively analyzed

including 109 cases of LVSI (-) and 37 cases of LVSI (+). Maximum apparent diffusion coefficient (ADC max )

ADC

min

and ADC

mean

of the two groups of patients were measured

and the differences of each parameter between the two groups were compared. Receiver operating characteristic (ROC) curve analysis was carried out to evaluate the diagnostic performance of ADC

min

and ADC

mean

in evaluating LVSI status in EC.

Results:

No statistically significant difference was found in ADC

max

between the two groups (

P

＞0.05).There was significant difference in ADC

mean

(

F

=13.832

P

＜0.001) and ADC

min

(

F

=19.927

P

＜0.001) between the two groups. The area under curve (AUC) of ADC

min

ADC

mean

for evaluating LVSI status in EC were 0.853 and 0.772 respectively. According to the optimal cut point

the sensitivity and specificity value of ADC

min

and ADC

mean

were 86.5% and 62.2%

71.6% and 82.6%. The diagnostic performance of LVSI evaluated by ADC min was significantly higher than ADC

mean

(

Z

=2.221

P

=0.026).

Conclusion:

Both ADC

min

and ADC

mean

are helpful for preoperative evaluation of LVSI status in EC

and ADC

min

has a higher diagnostic performance.