<sup>18</sup> F-FDG PET/CT在 <sup>131</sup> I治疗分化型甲状腺癌转移灶中的临床价值

盛矢薇; 王阳; 陆汉魁

doi:10.19732/j.cnki.2096-6210.2024.03.008

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¹⁸ F-FDG PET/CT在 ¹³¹ I治疗分化型甲状腺癌转移灶中的临床价值

论著 | 更新时间：2025-12-15

- ¹⁸ F-FDG PET/CT在 ¹³¹ I治疗分化型甲状腺癌转移灶中的临床价值
- Clinical value of ¹⁸ F-FDG PET/CT in ¹³¹ I treatment of metastases of differentiated thyroid cancer
- 肿瘤影像学 2024年33卷第3期页码：263-269
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- DOI：10.19732/j.cnki.2096-6210.2024.03.008
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- 网络出版：2024-07-16，
  
  纸质出版：2024-07-16
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盛矢薇,王阳,陆汉魁. ¹⁸ F-FDG PET/CT在 ¹³¹ I治疗分化型甲状腺癌转移灶中的临床价值[J]. 肿瘤影像学, 2024, 33(3): 263-269 https://doi.

org/10.19732/j.cnki.2096-6210.2024.03.008
盛矢薇,王阳,陆汉魁. ¹⁸ F-FDG PET/CT在 ¹³¹ I治疗分化型甲状腺癌转移灶中的临床价值[J]. 肿瘤影像学, 2024, 33(3): 263-269 https://doi. DOI： 10.19732/j.cnki.2096-6210.2024.03.008.

org/10.19732/j.cnki.2096-6210.2024.03.008 DOI：

摘要

目的：

探讨

F-FDG正电子发射体层成像（positron emission tomography，PET）/计算机体层成像（computed tomography，CT）在

131

I治疗分化型甲状腺癌（differentiated thyroid carcinoma，DTC）转移灶中的临床价值。

方法：

纳入DTC术后临床疑有转移灶的患者305例，实施

131

I治疗前均行

FDG PET/CT和其他相关的影像学检查，

131

I治疗后96 h行

131

I全身扫描（

131

I whole body scan，

131

I-WBS）和局部

131

I单光子发射计算机体层成像（single-photon emission computed tomography，SPECT）/CT。

131

I治疗前后动态检测患者血清甲状腺球蛋白（thyroglobulin，Tg）及甲状腺球蛋白抗体（thyroglobulin antibody，TgAb）水平变化。

131

I治疗后随访期均≥2年。

结果：

以血清Tg=10.0 ng/mL为阈值，Tg≥10.0 ng/mL组，62.1%（90/145）DTC患者在

F-FDG PET/CT图像上有高代谢转移灶；Tg＜10.0 ng/mL组，25.0%（40/160）患者在

F-FDG PET/CT图像上有高代谢转移灶；组间差异有统计学意义（

＜0.01）。动态随访结果显示：

F-FDG呈阳性者，血清Tg的初始均值较高，

131

I治疗无效比例也较高；

F-FDG阴性者，初始血清Tg水平较低，无论

131

I治疗是否有效，其后血清Tg可趋稳定或逐渐下降。

结论：

以血清Tg=10.0 ng/mL为阈值，可提高

F-FDG PET/CT判断DTC转移灶的阳性率，但有不确定性。

F-FDG PET/CT还有助于预判

131

I治疗

DTC转移灶的效果和病情转归。

Abstract

Objective:

To investigate the clinical value of

F-FDG positron emission tomography (PET)/computed tomography (CT) in

131

I treatment of metastases from differentiated thyroid cancer (DTC).

Methods:

A total of 305 cases with DTC metastases were included in this study.

F-FDG PET/CT as well as other routine imaging diagnostic methods were carried out before

131

I treatment

followed by

131

I-whole body scan (WBS) and

131

I single-photon emission computed tomography (SPECT)/CT 96 h later. Dynamic serum thyroglobulin (Tg) and thyroglobulin antibody (TgAb) immunoassay was performed pro-

131

I treatment and follow- up for at least two years.

Results:

With cutoff value of serum Tg=10 ng/mL

in cases with serum Tg≥10 ng/mL

62.1% (90/145) cases with DTC metastases were found with positive lesions on

F-FDG PET/CT images. In cases with serum Tg＜10.0 ng/mL

only 25.0% (40/160) cases were found with positive lesions on

F-FDG PET/CT

significantly lower than those former cases (

＜0.01). Dynamic follow-up data showed that those cases with

F-FDG positive and initial high serum Tg were related with high probability of invalid

131

I treatment or unfavorable outcomes. On the other hand

those with negative

F-FDG uptake were more likely associated with low initial serum Tg and came off with either effective

131

I treatment or gradual decline of serum Tg during the follow-up.

Conclusion:

The cut off value of serum Tg=10.0 ng/mL may well be evident for

F-FDG PET/CT indication for the patients with DTC metastases

those some uncertainties remained unresolved.

F-FDG PET/CT imaging results also help predict the outcomes of

131

I treatment and follow-up.

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DOI：10.19732/j.cnki.2096-6210.2024.03.008

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Abstract

关键词

Keywords

references

¹⁸ F-FDG PET/CT在 ¹³¹ I治疗分化型甲状腺癌转移灶中的临床价值

Clinical value of ¹⁸ F-FDG PET/CT in ¹³¹ I treatment of metastases of differentiated thyroid cancer