实时弹性成像联合超声造影对甲状腺TI-RADS 4类结节良恶性诊断价值的研究

周超; 徐新艳; 沈波; 朱正

doi:10.19732/j.cnki.2096-6212.2018.06.014

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实时弹性成像联合超声造影对甲状腺TI-RADS 4类结节良恶性诊断价值的研究

论著 | 更新时间：2025-12-15

- 实时弹性成像联合超声造影对甲状腺TI-RADS 4类结节良恶性诊断价值的研究
- Value of real-time elastography combined with contrast-enhanced ultrasound in differential diagnosis of TIRADS category 4 nodules of the thyroid
- 肿瘤影像学 2018年27卷第6期页码：493-498
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- DOI：10.19732/j.cnki.2096-6212.2018.06.014
  中图分类号：
- 网络出版：2019-01-16，
  
  纸质出版：2019-01-16
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周超,徐新艳,沈波,等. 实时弹性成像联合超声造影对甲状腺TI-RADS 4类结节良恶性诊断价值的研究[J]. 肿瘤影像学, 2018, 27(6): 493-498 https://doi.

org/10.19732/j.cnki.2096-6212.2018.06.014
周超,徐新艳,沈波,等. 实时弹性成像联合超声造影对甲状腺TI-RADS 4类结节良恶性诊断价值的研究[J]. 肿瘤影像学, 2018, 27(6): 493-498 https://doi. DOI： 10.19732/j.cnki.2096-6212.2018.06.014.

org/10.19732/j.cnki.2096-6212.2018.06.014 DOI：

摘要

目的：

探讨实时弹性成像（real-time elastography，RTE）联合超声造影（contrast-enhanced ultrasound，CEUS）对甲状腺影像报告和数据系统（Thyroid Imaging Reporting and Data System，TI-RADS）4类结节良恶性的研究诊断价值。

方法：

选取二维超声诊断为甲状腺TI-RADS 4类结节的102例患者共115个结节，依次行RTE及CEUS检查，以手术后病理学检查结果为金标准，分别绘制两种方法单独及联用的受试者工作特征（receiver operating characteristic，ROC）曲线，比较曲线下面积（area under curve，AUC），评价两种方法单独和联用对甲状腺TI-RADS 4类结节的诊断价值，并分析漏诊及误诊原因。

结果：

115个甲状腺TI-RADS 4类结节中，病理学诊断恶性58个，良性57个。RTE诊断甲状腺癌的灵敏度、特异度及准确率为82.75%、84.21%及83.48%。CEUS诊断甲状腺癌的灵敏度、特异度及准确率为86.21%、89.47%及87.83%。联合RTE与CEUS诊断甲状腺癌的灵敏度、特异度及准确率为82.75%、96.49%及89.57%。RTE、CEUS及两者联用的AUC分别为0.835、0.878及0.896，各诊断方法之间差异无统计学意义（

＞0.05）。

结论：

RTE、CEUS及两者联用对TI-RADS 4类结节均有较高的诊断价值，需综合分析。

Abstract

Objective:

To investigate the value of real-time elastography (RTE) combined with contrast-enhanced ultrasound (CEUS) in the differential diagnosis of Thyroid Imaging Reporting and Data System (TI-RADS) category 4 nodules of the thyroid.

Methods:

A total of 102 pa

tients with 115 TI-RADS category 4 nodules of the thyroid undergoing conventional two-dimensional ultrasound were given RTE and CEUS examinations. The receiver operating characteristic (ROC) curves of the two methods alone or combined were drawn and the area under curve (AUC) was compared.

Results:

Among 115 nodules

58 were malignant and 57 were benign. The sensitivity

specificity and accuracy of RTE in the diagnosis of thyroid cancer were 82.75%

84.21% and 83.48%

respectively. The sensitivity

specificity and accuracy of CEUS in the diagnosis of thyroid cancer were 86.21%

89.47% and 87.83%

respectively. The sensitivity

specificity and accuracy of combined RTE and CEUS in the diagnosis of thyroid cancer were 82.75%

96.49% and 89.57%

respectively. The AUC of RTE

CEUS and RTE+CEUS was 0.835

0.878 and 0.896. There was no statistical difference among the three methods (

＞0.05).

Conclusion:

RTE and CEUS alone or combined have high diagnostic value for TIRADS category 4 nodules of the thyroid

and comprehensive analysis could improve the accuracy of diagnosis of thyroid cancer.

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