Objective:

To analyze the value of magnetic resonance diffusion-weighted imaging (DWI) combined with serum microRNA-375 (miR-375) level in evaluating the risk of long-term lymph node metastasis in patients with cervical cancer (CC) after laparoscopic hysterectomy.

Methods:

A retrospective analysis was conducted

the data of 47 CC patients who had long-term lymph node metastasis within 3 years after laparoscopic hysterectomy in Danzhou Peoples Hospital from January 2016 to April 2018 were collected and included in the lymph node metastasis group; another data of 47 CC patients who did not have long-term lymph node metastasis within 3 years after laparoscopic hysterectomy during the same period were collected and included into the non-lymph node metastasis group. All patients received DWI and serum miR-375 detection before operation

and the case data and related examination data were complete. The baseline data of the two groups were collected and compared

the value of DWI combined with serum miR-375 level in evaluating the risk of long-term lymph node metastasis in patients with CC after laparoscopic hysterectomy was analyzed.

Results:

The apparent diffusion coefficient (ADC) value of lymph node metastasis group was lower than that of non- lymph node metastasis group

the difference was statistically significant (

P

＜0.05); the serum carcinoembryonic antigen (CEA)and carbohydrate antigen (CA)125 levels in lymph node metastasis group were higher than those in non-lymph node metastasis group

and the miR-375 level was lower than that in non-lymph node metastasis group

the differences were statistically significant (

P

＜0.05); there was no statistical significant difference in other baseline data between the two groups (

P

＞0.05). The results of logistic regression analysis showed that the increased level of miR-375 might be a protective factor of lymph node metastasis in patients with CC after laparoscopic hysterectomy (

OR

＜1

P

＜0.05). Th

e receiver operating characteristic (ROC) curve was drawn and showed that the area under curve (AUC) of ADC and miR-375 single and combined detection to evaluate the risk of long-term lymph node metastasis in CC patients after laparoscopic hysterectomy were ＞0.80

all of them had certain predictive value

and the joint detection evaluation value was higher.

Conclusion:

ADC value examined by DWI combined with serum miR-375 level have certain application value in evaluating the risk of long-term lymph node metastasis in patients with CC after laparoscopic hysterectomy.